I laugh everytime I 2000see Goldeneye where Bond walks into the room and he is in a wheal chair. Bond says something like, "Sorry for what happened, skiing accident?"
And Q's cast shoots off and explodes like a missle: "Hunting."
haha.

Not really a quote by Q, but I love his reaction in the world is not enough when bond is running and yelling 238past him at the MI6 HQ

"007 I haven't time for these childish antics!"

All Desmond quotes
Vijay

• "Is he still there?"
  Q
• "You must be joking! Double-0 seven on an island populated exclusively by women? We won't see him till dawn!"
  Q
• "It is to be handled with special care!"
  Bond
• "Everything you give me"
  Q
• "is treated with equal contempt. Yes, I know."
  Q
  [being kissed by Octopussy's girls after knocking out a bandit]
  Cut it out! We don't have time for that! Later perhaps.
  With your feet in the air and your head on the ground, try this sig with spinach!

Surprised no one has posted this yet. Always my favorite:
Q: It's the insurance damage waiver for your beautiful new car. Now, will you need collision coverage?
007: Yes.
Q: Fire?
007: Probably.
Q: Property destruction?
007: Definitely.
Q: Personal Injury?
007: I hope not, but accidents do happen.
Q: They frequently do with you.
007: Well, that takes care of the normal wear-and-tear. Is there any other protection I need?
Q: Only from me 007, unless you bring that car back in pristine order.
Signature:

Minister of Denfence: My God what's Bond doing?"
Q: I think he's attempting re-entry sir!
007: Forgive me Father for I have sinned
Q: That's putting it m238ildy 007!
007: Ejector seats, you're joking!
Q: I never joke about my work 007
007: Q have I ever let you down?
Q: Frequently
Q: Do try and return some of this equipment in pristine order DON'T TOUCH THAT!!! That's my lunch!
007: Somebody seems to have stuck a knife in my wallet
Q: They missed what a pity!
007: Do I need any protection?
Q: Only from me, 007, unless you bring that car back in pristine order
After 007 has thrown Moneypenny his hat after his wedding and Q takes it off her.
Q: He never had any respect for government property!
And these 2 aren't from Q but about him
After 007's car has been sawn in half.
007: Q's not gonna like this!
When Q walks in to meet 007 in Thunderball
007: Oh no!

It definitely had to be his last lines in TWINE:
Q: "Now, 007, I've always tried to teach you 2 things; Never let them see you bleed."
Bond: "And the second?"
Q: "Always have an escape plan!"
That was the last time we saw Q.

Too many to list, but I have a particular favorite from The World Is Not Enough
Bond: I suppose we all have to pay the piper sometime.
Q: Oh, pipe down, 007!
Bond: Was it something I said?
Q: No, something you destroyed!! ("My fishing boat, for my retirement. Away from you.")

"Now pay attention 007" That's my favorite one.

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cloverandcrimson you have such a good point to be in a scene with the ery same Q he probably grew up watching would be amazing, for me anyway

Shame about "the equipment" though BMW Z3 as the bond car wtf!

TWINE- "Always have an excape plan"

My fav was in T.W.I.N.E when Bond sees the boat he brought back, I forgot the line , iw was like, " that was my boat for my retirement, away from you!"

Bond:They said the pen was mightyier then the sword?
Q:well thanks to me they were right!

I think its the tone of his voice that does it, i love him
"Don't touch that, thats my lunch"
"You have a license to kill, not to break the traffic laws"
"Oh grow up 007"
"The writing's on the wall, along with the rest of him"
I'll get you yet John McClane!

no one has mentioned moonraker
Bond: BALLS Q?
Q: (seemingly piss ed off) BOWLES007
Q: Be careful, will you? Now, there's ten darts: five blue-tipped, armour-piercing; five red-tipped, cyanide coated, causing death in thirty seconds.
Bond: Very novel, Q. Must get them in the stores for Christmas.
(also, from a view to a killi loved this one)
Q: (about Mayday) She must take a lot of vitamins!
James Bond: Yes, and perhaps Pegasus does too.
Watch Your Back, Jack