They grew apart and out of love.
She's never been with anyone else.

hellyezz it does

Gives all her fanboys hope

Not everyone wants children. Shocking, but true.

Maybe she feels too old to start raising a kid now, Janet Jackson notwithstanding?

On The Talk she says quite a bit about how she likes to fill every minute of her day with work of some sort. I always wondered where did her husband fit into this schedule? Though, maybe she was pushing her professional life so hard to avoid her home life? It's sad though. If it was the baby issue, they could have adopted or used a surrogate mother. Career should never be more important than family. On your death bed you will never wish you'd had one more day to work!

Not really sure. Maybe it had something to do with the children issue. I wish her all the best.