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John Witherspoon as FRED G. SANFORD
Brian Hooks (from 3 Strikes) as LAMONT (He'd look just like Lamont with an afro wig!)
Alternately, Chris Tucker could do LAMONT good if they'd pay him what he would want.
Mike Epps would be the perfect ROLLO
John Leguizamo is perfect as JULIO
Will Ferrell is perfect as OFFICER HOPPY
Bernie Mac would be a pretty good OFFICER SMITTY
Terrance Howard would make a good GRADY WILSON (Imagine him with a grey afro and beard, he already has eyes like Whitman Mayo, the original GRADY. Plus Terrance is funny.)
Bebe Drake would be the ultimate AUNT ESTHER
Dave Chappelle could do UNCLE WOODY pretty good
Anthony Anderson would be the perfect BUBBA
Faizon Love could be a good SKILLET
Jo Marie Payton-France could be a good DONNA (Fred's Love Interest)
Jackie Chan would be a funny AH-CHEW (Remember Pat Morita's character?)
Also the movie wouldn't be complete without allowing Demond Wilson, the original LAMONT to do some type of cameo role. Maybe a church scene as the pastor since he is now a minister in real life. Plus it would be a good scene because in the series, we never saw Aunt Esther's church, although she was very religious. The plot could be Esther finally convincing Fred to attend church.
I heard that they are in talks to do a Sanford &amb68p; Son movies with Bernie Mac as FRED and Nick Cannon as LAMONT, which by the way would be a big mistake.

DAMN! These are some great choices
Here's Mine:
Spoon as Fred G.
D-Ray Davis could play Lamont
Snoop would be a great Rollo
Bill Cobbs as Grady
Leguizamo as Julio & BeBe Drake Moore as Esther are good choices
Chi McBride as Smitty
Jim Gaffigan as Hoppy
Cedric The Entertainer as Bubba
Gary Anthony Williams as Leroy
LaVan Davis as Skillet
Lou Myers as Woodrow the wino
Diahann Carroll as Donna
Kelly Coffield as Mrs. Hopkins
Larry The Cable Guy as Cal (from Sanford)
** update **
Dammit.. I just read on line that they have tapped Bernie Mac and WTF Nick Cannon to star in the movie..!
Sounds like a box-office BUST!!!! If they have them 2 as Fred & Lamont.. I have no desire to watch it..!

wanda sykes?
I'm not better than you, not worse either.
No, wait, I am better than you. Never mind.

Kim Wayans as Aunt Ester!

Yeah.
Shawn Wayans would make a better one

This cast is good, except Dave Chappelle is a little too edgy for Lamont's character.

What about Leroy and Skillet?
You have failed me for the last time,Admiral-DARTH VADER

LOL. actually I could see Chris Rock playing Rollo, too

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Hey Panic, you have come up with a great cast. I hope that they try to make that movie also. Do you have a role for Chris Rock? Lol

LOLOLOLOLOLgood choices!!

Like they would ever do a Sanford and Son movie, but I wish they would.

BeBe Drake Massey as Aunt Esther
Bruce Bruce as Bubba