Penguins is one of the best cartoon series of 2000s

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I LOVED The Adventures of Jimmy Neutron: Boy Genius when I was a little girl. Although I didn't know what a real crush was yet, I developed one on him lol. Why was life funny as us little children?
Goddamnit, man! You done made me hurt my dick hand. (Phone Booth, 2002)

I have plenty of favorites from the 2000s but my top 10 shows are: Futurama, The Venture Bros., Ed Edd n Eddy, Family Guy, South Park, Invader ZIM, Jackie Chan Adventures, Teen Titans, Samurai Jack, and Avatar: The Last Airbender.
Honorable Mentions:
Teenage Mutant Ninja Turtles 2003
The Spectacular Spider-Man
Batman Beyond
X-Men: Evolution
Justice League
Duck Dodgers
Aqua Teen Hunger Force
The Brak Show
The Boondocks
Metalocalypse
Robot Chicken
Tom Goes to the Mayor
Action League Now!!
Sponge Bob Square Pants (until 2004)
The Fairly OddParents (until 2005)
Lilo & Stitch: The Series
Codename: Kids Next Door
My Life as a Teenage Robot
What's New, Scooby-Doo?
¡Mucha Lucha!
Static Shock
Xiaolin Showdown
Time Squad
The Grim Adventures of Billy & Mandy
The Life and Times of Juniper Lee (an underrated show)
Megas XLR
Hi Hi Puffy AmiYumi
Grossology
Totally Spies!
Code Lyoko
Kim Possible
Clerks (too bad it was so short lived)
Home Movies
Mission Hill
Baby Blues
Drawn Together

Oh yes, those are two of my favorites as well - and my daughter's, too!
Let us be realists, let us demand the impossible.

Hi,
my favorite animated TV series are:
-Mr. Bean: The Animated Series
-The Fairly OddParents

Justice League
(
https://en.wikipedia.org/wiki/Justice_League_(TV_series
) is amazing,
The Powerpuff Girls
(
https://en.wikipedia.org/wiki/The_Powerpuff_Girls
) is amazing and funny, and
Grossology
(
https://en.wikipedia.org/wiki/Grossology_(TV_series))
is funny and partially educational for a show that wasn't on PBS or on TV Ontario (a pubic broadcaster in Ontario, Canada.)

Oh yeah, "Kim Possible" is great! I'm afraid I haven't seen "Justice League" and "Grossology", and I don't remember "Powerpuff Girls" too well
Let us be realists, let us demand the impossible.

Kim Possible
2.
Justice League
3.
Grossology
4.
Powerpuff Girls

Some good ones have been listed so far. I'm an early 90s baby and an avid cartoon lover so I was always coming across funny & weird ones. Here's some of my favorites (with some only beginning in the 2000s)..
Rugrats
CatDog
Hey Arnold
Invader Zim
Danny Phantom
Jimmy Neutron
The Fairly Oddparents
Chalkzone
Avatar: The Last Airbender
South Park
King of the Hill
Futurama
The Grim Adventures of Billy & Mandy
Regular Show
The Oblongs
Archer
Mission Hill
Cowboy Bebop
Rocket Power
As Told By Ginger
The Boondocks
Daria
Pepper Ann
Arthur (Still airing I believe)
Dexter's Lab
Powerpuff Girls
Home Movies
Sealab 2021
Aqua Teen Hunger Force
Samurai Jack
Johnny Bravo
Courage the Cowardly Dog
Ed, Edd, & Eddy
The Venture Bros.
Bob's Burgers
Drawn Together
Pretty much anything on Adult Swim back then, lol.
Some might not be kid-friendly with the content they focus on, but they're alright for adults!
Judge not unless you judge yourself - Bob Marley

Ed, Edd & Eddy
Dexter's Lab
Cartoon Planet

Yes, there's the by now almost 'classic' episodes from the early 00s, and a couple of years ago new episodes were made; but I don't like those too much, I must admit.
Let us be realists, let us demand the impossible.

Don't you mean the 2003 and 2012
Teenage Mutant Ninja Turtles
shows?

Ooh, I'm afraid I must shamefully admit that I've never seen "South Park" or "Futurama" But yeah, the "Teenage Mutant Ninja Turtles" sure are great, they're showing them in repeats these days on Greek TV!
Let us be realists, let us demand the impossible.

South Park (even if it does go a bit overboard at times) and Futurama (not as good as 90s Simpsons but much better than 00s Simpsons).
Oh, and not forgetting the 2003 version of Teenage Mutant Ninja Turtles!

are you right.
http://thebegetter.com

Ah, yeah, you're quite right, those were two pretty unusual shows as well!
Let us be realists, let us demand the impossible.

Definitely Spongebob.
Rocket Power, As Told By Ginger, and My Life As A Teenage Robot were good shows as well.
Nice 2 laugh, but don't be the joke.

Aqua Teen Hunger Force. Complete hilarity and manages to tell an insane story in just 12 minutes of time. Video Ouija.

Thank you VERY much!!
Let us be realists, let us demand the impossible.

Hope you enjoy it! It's definately unique and hilarious! Happy to share anytime!
Dream With The Feathers Of Angels Stuffed Beneath Your Head CLUTCH

Thanks a lot for teaching me something entirely new! I just looked it up on IMDb, because I'd never heard about it before; so it was about 10 years ago, a kind of latter-day "Muppet Show", but maybe even more crazy - and THAT sure is saying something!!
Let us be realists, let us demand the impossible.

There was this CRAZY funny show with puppets called WONDERSHOWZEN. It came on late at night and I dont recall what network it was on. Even the theme and opening was insanely funny. I miss it!
Dream With The Feathers Of Angels Stuffed Beneath Your Head CLUTCH

Ah, the Simpsons, of course (and it shows from your avatar that you're a fan!); they were hugely popular, yes, and VERY funny! While I must admit that I've never seen "King of the Hill"
Let's be realists, let's demand the impossible.