Some unique horrors, or interesting takes on established sub-genres
Triangle
Rammbock
Pontypool
Warm Bodies
Fido
Splinter

Cube (1997) - Unique plot and surprisingly gory

It Follows

The Earth Dies Screaming

Bad Biology
Don't give up the fight for truly independent cinema!

The Strange Color of Your Body's Tears and The Girl Walks Home Alone at Night are worth a look for not so standard fare
According to me, yes. I am the person it's usually according to when I'm talking.

Darling was a surprise for me during the challenge. Absolutely loved it. You might dig that one. It's about a woman going mad while watching a haunted house It's is unique despite a not very original premise.
According to me, yes. I am the person it's usually according to when I'm talking.

Dead & Buried
www.thecultofhorror.blogspot.com

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Definition of unique - having no like or equal; unparalleled; incomparable.
Well, everything is pretty well borrowed from something. How about
Tucker and Dale vs Evil (2010)
The Troll Hunter (2010)
The Descent (2005)
Trick 'r Treat (2007)
Pandorum (2009)
American Mary (2012)
October challenge -
http://www.imdb.com/list/ls066581682/

Exactly. The actors had really good chemistry and there was a sense that the two characters had truly known each other for years.

I'm glad you liked it, Eseh. On my first viewing, I was drawn into the well-written relationship between the two friends. Good acting too. It was so realistic and unusual that it didn't even need to be a horror movie- that was an added bonus, in some respect, at least for me.

I thought this movie was going to be so-so at best and was pleasantly surprised. Great little movie.

Resolution (2012)
http://www.imdb.com/board/11977895/?ref_=fn_al_tt_1
Currently my favorite horror film. I've watched it at least a dozen times, and I notice new details on every fresh viewing. Both the leads are immensely likable, and their bond anchors a gripping narrative that can never really be resolved, oddly enough.
Best Indie Horror Movies:
http://www.imdb.com/list/ls070522782/

Escape from Tomorrow (2013)
Banshee Chapter (2013)
Starry Eyes (2014)
Found Footage Movies I Have Seen:
http://www.imdb.com/list/ls059758083/

so a vampire, sci fi n zombie flick that are 'unique'
I'd say 28 Days Later is quite a unique zombie film, in that it has no zombies in it.

I was mostly schlurbed when I watched
yeah, i know that town brother
Tex Monta Will Survive was thier next one, not seen it yet and not sure what sort of release, if any, it got.

Haven't seen your other recs, but great call on The Battery - I was mostly schlurbed when I watched, but eez good quality and I loved the ending. They put out a call for viewer investment on their next project. I forget what happened.
Flowers is the uniquiest horror I've watched:
http://www.imdb.com/board/14248930/?ref_=fn_al_tt_6

so a vampire, sci fi n zombie flick that are 'unique', by which i'm going to assume you mean non generic, original takes but still good movies.
i'll go Livide, From Beyond & The Battery for ech genre respectively

It probably owes as much, or more, to The Last Man On Earth (1964) and Day Of The Triffids than any Romero film

C'mon now, you know 28 Days Later is unique if you ignore the fact it borrowed from previous George Romero movies.
I collect dead pigeons then I press them between the pages of a book.

Right, I'll churn the old noodle and post any unique zombie movies I can think of..

28 Weeks Later.

No. Something unique like 28 Days Later.