Since I never watch current movies, I had to look up all of the aforementioned actresses' images on internet. None of those stringy chickens are even close to Allison Hayes in the figure department.
He maketh his sun to rise on the evil and on the good St. Matthew 5:45

I see it more with Jennifer as the 50 footer; with Brad and Angelina.
That wasn't very sporting, using real bullets.

Angelina Jolie as the 50 footer, Brad Pitt and Jennifer Aniston.

Are we talking a halfway serious effort or pull-out-all-the-stops campy?
Kristen Bell, perhaps. Playing an introverted little woman with hidden anger issues. Make the radiation capable of turning people, not necessarily taller, but into whatever their id wants them to be (large and fearsome, in her case).
And Dax Shepard as her rotter of a husband.
Maybe Sophia Bush as the girlfriend not nearly as evil as clueless and manipulated.

There was a remake in 1993 and Nancy Archer was played by Daryl Hannah.

Now
there's
somebody paying attention to casting.

I don't know about the main character, but I think Tracy Lords would be pretty good evil girlfriend of the husband character.

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It's already been remade.in 1993, directed by Christopher Guest with Daryl Hannah as the 50 Foot Woman. I doubt you'll be getting another remake.

I'd like to see Blake Lively myself.
"Mein Fuhrer, I Can Walk" Dr. Strangelove

Cameron Diaz or Jessica Alba.