Randy Quaid and Louis Gosset, Jr. Oh yeah.. make Gosset an alien.
wait a minute.
Anal Nathrach thvas Bethod Dochiel Dienveh

While racism still exists, I don't think people would relate to a film using a black and a white as much as they would in the 60s. But at least it would be better than the Star Trek episode in which one alien was black on the right and white on the left and the other alien was white on the right and black on the left.
I would like to see either a Palestinian teamed with an Israeli Jew or a German neo-Nazi skinhead teamed with a radical Muslim. While you probably need somewhat known actors in order to make any money, I think it would be neat to have actors from the same countries they represent in the film.
You could change it to use women, but I find it easier to think of opposing women cooperating than opposing men.

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Don't need a remake.
We already got the same pieta image of Cullen holding Joker in his arms some 31 years later with Lethal Weapon 2 starring Danny Glover and Mel Gibson.

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I like the remake from 1986 with Weathers and Urich. Too bad, I can't find it anywhere.
48hrs with Murphy and Nolte has got something from the defiant ones too.

Denzel Washington and Tom Hanksmaybe a few years ago.

Jay and Silent Bob! and Chris Rock! (Oh wait they already did that. Damn!)

Noah: Michael Jai White
Joker: Josh Brolin

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50 Cent and Billy Bob Thorton

good call! I stumbled onto this thread and thought the same thing"Fled"!