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No more remakes. The Odd Couple has been done in so many different versions that it does not ever need to be done again!

Paul Rudd as Felix and Jason Segel as Oscar could work. They've already kind of played a similar dynamic in "I Love You Man," and it worked splendidly if you ask me.

Paul Giamatti for Felix, and Thomas Haden Church for Oscar. See the film
Sideways
for reference.
Or perhaps, Steve Carell as Felix, and Louis C.K. as Oscar.
Fun Fact - James L. Brooks stated that Jack Nicholson is the only actor who could successfully play both Felix
and
Oscar.
Which, in my opinion, he has - Garrett Breedlove in
Terms of Endearment
is essentially Oscar Madison, while Melvin Udall in
As Good As It Gets
, is basically Felix Ungar.

Jack Black and Jason Sedeikis

Felix is easy: Jim Parsons. He might be the only person on the planet that could pull that role off right now.
Oscar would be interesting, because he was a "man's man." In that day and age that largely meant a slob. A true remake would reimagine Oscar as today's man's man. With that in mind, I'd go away from the Matthau type toRyan Gosling.
A traditional "Oscar" type would be Seth Rogan. He could do the annoying slob part well.

With the scene reset in Austin, TX: Jack Black as Felix; Woody Harrelson as Oscar; Conan O'Brien and Tilda Swinton as the Pigeon brother and sister (in my version, Felix is gay); Will Ferrell as Murray the Cop; Zack Galifanakis as Vinnie; Harvey Keitel and Robert DeNiro as Roy and Speed (they're New York transplants); and Arnold Schwarzenegger as the poker table.

Max Von Sydow as Felix; the volleyball from "Cast Away" as Oscar.
"I will not go down in history as the greatest mass-murderer since Adolf Hitler!" - Merkin Muffley

Billy Bob Thornton as Oscar and John Cusack as Felix

Norm McDonald as Oscar and David Spade as Felix
or
Chris Rock as Felix and Tracy Morgan as Oscar

Arnie Schwarzenegger as Oscar Madison and Danny DeVito as Felix Unger -
Oscar: "Ahl be bahk!"
Felix: "Pick up some more pomentos from the deli!"

Simon Pegg and Nick Frost.

I would never actually recommend a remake of the movie, because I agree with the consensus in this thread that Lemmon and Matthau's performances were brilliant (and likely cannot be improved upon). However, I don't mind playing the "what if" game just to see who people come up with. Plus I liked the idea of framing this question as who would we like to see in the roles during a revival of the play instead of a remake of the movie.
My pick for Felix would be Jim Parsons. I was recently re-watching the movie for probably the first time since really becoming aware of Jim's work a couple of years ago (I was a bit slow in giving The Big Bang Theory a try, though I've now become a devoted fan), and it suddenly struck me that Jim would likely be a perfect fit for all of Felix's obsessive and outrageous quirks. Playing Sheldon has certainly given him some experience with the role of a quirky roommate, but it would be interesting to see that played against a roommate who is much more his opposite than Sheldon's current friends. Plus, Jim appears to have a lot of experience on the stage as well. I saw clips of him in Harvey and thought he did a nice job of playing another eccentric character (without making him feel like merely a carbon copy of Sheldon).
I have yet to come up with a pick for Oscar though. I'm still thinking on that one.

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I only like this kind of a discussion as a hypothetical.
What about Jack Black as Oscar? I am still thinking about a Felix who hasn't been mentioned.

If they did a movie of the female version, I can see Ali Larter as Florence (Felix) and Amy Smart as Olive (Oscar).

Robert Downey Jr. and Mark Wahlberg are my picks.

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Good advice

Charlie Sheen and Jon Cryer- No Wait

If we could resurrect Walter Matthau and Jack Lemmon from the dead I think we'd be set.
My point is, no remake.
You can't remake perfection.

My first choices;
Charlie Sheen - Oscar
William Macy - felix
But let's hope they don't attempt to remake this classic flick since it will just be another embarrassing remake flop.

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