I don't think she knew and at the end I think she was just glad he was alright.
Wayne Enterprises buys and sells companies like Stark Industries

Wow 4 years later and I'm still getting replies. Thank you.
Once the game is over, the king and the pawn go back in the same box

the way that i took it is that she doesn't know. at the end when she sees him on the ledge, she starts crying, but then it seems to me that she starts laughing; and i always took it that she was laughing because she thought his friends had played some kind of joke on him to get him into that predicament.

Also remember the scene at his surprise birthday party with Charlotte and his wife is looking at her very curiously; it's obvious she suspects something is up.
"When we make mistakes, it's evil. When God makes mistakes, it's nature."

I think the scene at the end where she sees him on the ledge and tears fill her eyes indicates she knows he is in distress and it must involve another woman.

I think it's intended to be ambiguous. Because what other reason would have had his wife to play the jealous scene (the shot undies scene), or the scene where Teddy goes to calm down his "crazed" buddy and she looks at them sad, like she knew what was going on?
Gognitti bailed. I made like Chow Yun-Fat.