Interesting. Alas I'd say chances are rather low. Whedon has signaled in the past that he feels Firefly's time is done.

Being a huge fan, I would still really like to see maybe a reboot of Firefly from Joss. My ideal scenario would be to ditch the comics and Serenity, bring back Mal, Zoe, Wash and Kaylee, Simon and River (maybe not all of them at once, maybe some of them would only appear in certain episodes) then bring in some fresh new characters and a new threat.
This Joss could do. And sadly, the silence is very telling. He did not jump on this chance, and he did not even respond officially on it. Which is very-very sad
I was looking back to see if you were looking back at me to see me looking back at you

Nah. Everyone's pretty much moved on. I think the fans are the only ones still really hanging on.
Seize the moment, 'cause tomorrow you might be dead.

Do you see a snowball's chance in hell that Joss would grab this opportunity to pick Firefly up again with FOX?
I was looking back to see if you were looking back at me to see me looking back at you

I think they treated Dollhouse a little better than I expected. It was actually given a renewal for a second season. Even Joss has said he was surprised since it gave him a chance to wrap up most storylines.
Seize the moment, 'cause tomorrow you might be dead.

Sadly, this is almost a decade too late.
Joss was still working with FOX in 2009, but after they treated Dollhouse as they did, I don't really see a chance that this will come into fruition.
The funny thing is that I still did not see any official response from Joss. I would like to hear him react to this, gorram it!
I was looking back to see if you were looking back at me to see me looking back at you

Source.
https://editorial.rottentomatoes.com/article/tca-2017-x-men-series-prison-break-premiere-date-24-legacy-gotham-more/
Fox Open to Firefly Reboot
if Joss Whedon Wants To
Given the success of Fox's reboots of
The X-Files
and
24,
and
Prison Break
returning this year, [Fox Broadcasting President of Entertainment David] Madden said
he'd be open to a Firefly reboot
if Joss Whedon himself wanted to revisit it.Madden suspects Whedon is now too busy with movies, and he would not consider doing Firefly without Whedon.

BDH is Big Damn Heroes.
And yes, I would like to see the sources too.
Seize the moment, 'cause tomorrow you might be dead.

What are you saying? What is BDH, and where did you hear mumblings? sources?
~I swear, I need a cocktail, and a lobotomy~ (Maria Hill, Agents of Shield)