Penny: I'm a Sagittarius, which probably tells you way more than you need to know.
Sheldon: Yes, it tells us that you participate in the mass cultural delusion that the suns apparent position relative to arbitrarily defined constellations at the time of your birth somehow affects your personality.

"You made god sad today mom." Followed by the awkward walk past.

"I cry because others are stupid and that makes me sad"
"I am not insane my mother had me tested"

"Dear lord! Are you still going to be here on French toast day?!"

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Winning the world series of Sheldon lines:
"SHE WAS LATEand I wouldn't coitus her with YOUR genitals"
MIKE DROP
"Who's Mike Drop?"

To Penny: "I've seen pictures of your mother, keep eating."
"No muss, no fuss, not a single cuss."
"Thiospinel sulfide! Beep-bop-boop-bop!"
"Einstein Von Brainstorm"
Leonard: You'll never guess what just happened.
Sheldon: You went out in the hallway, stumbled into an inter-dimensional portal, which brought you 5,000 years into the future, where you took advantage of the advanced technology to build a time machine, and now you're back, to bring us all with you to the year 7010, where we are transported to work at the think-a-torium by telepathically controlled flying dolphins?
"And if he has twins, we can do all kinds of neat experiments on them."
Leonard: I did a bad thing.
Sheldon: Does it affect me?
Leonard: No.
Sheldon: Then suffer in silence.

"The Germans have always been a comforting people."
"Can I interest you in a topical steroid from my lotion and unguent collection?"
"Not knowing is half the fun? What is that, the motto of your community college?"
"Don't wake her; she'll maul you like a rabid wolverine."
Amy: "You can't regulate every aspect of our lives."
Sheldon: "I can if you'd just roll over and accept your fate."
"Two gin and Frescas"
"Shaken, not ridiculed"

"I possess the DNA of LEONARD NIMOY?!?!"
The first time I heard, "All I need is a healthy ovum and I can grow my own Leonard Nimoy!", I was laughing so hard I missed Penny's response.
.
Mr Smith: Like the rose trampled on the ground, you took the fall

When he's talking about superman catching Lois lane and how it would chop her intoieved how it would be kinder to let her fall.
when someone says 'you catch more flies with honey than vinegar' and he responds 'you catch more flies woth manure'