Disney has showed they can take flops like those without too much problem
Well ESPN annual revenue (11 billion) alone is the equivalent of 10 Star Wars Force Awaken movie box office revenue.
The whole home run or strike out mentality seems risky, but its working,
It is going extremely well:
Revenues:
Media Networks $ 23,264
Parks and Resorts 16,162
Studio Entertainment 7,366
Consumer Products 4,499
Interactive 1,174
Total:52,465
Segment operating income:
Media Networks $ 7,793
Parks and Resorts 3,031
Studio Entertainment 1,973
Consumer Products 1,752
Interactive 132
Total: 14,681
As you see the complete studio entertainment segment is 14% of Disney revenue and 13.4% of the profit in a very good year for them (26% margin is crazy for studio entertainment).
The only going for big franchise movie or swinging to create new one, create IP to put into the parks and consumer products. They are probably ok and happy as long as some of them become franchise they can put in their park and merchandise (and you cannot have more than X of those I guess, or they cannibalize each other anyway). A successful one for Disney pay much more and for a decade (pumping sequels, park attraction, merchandises, etc) than a major failure cost them (a one time and limited cost).

They already did with the huge overruns on Lone Ranger and John Carter, but Disney has showed they can take flops like those without too much problem. The whole home run or strike out mentality seems risky, but its working, and I bet they would be fine with their other movies even if Pirates 5 is a worst case outcome.

Ouch. If it did break the 300 million barrier, it is going to cut into the profits. Oh,it will make money,but IMHO Disney is playing Russian Reloutte with these constant huge overruns,and someday the gun will go off.

Dom: $206
WW: $938
It doesn't look that out of touch to be fair. I think Transformers is a good comparison for this series. The last film lost a third of its domestic audience and about 10% of its non-Chinese foreign audience, so a similar scenario here would result in $180 million domestic and $800-900 million worldwide (excluding China).
The foreign exchange rate has taken a severe pounding in the last couple of years though, losing at least 20% of its value everywhere except Asia, so let's say there is another 25% drop across the non-Asian foreign markets then that would bring the total down to around $700 million (still excluding China).
In the same period the Chinese gross doubled for Transformers, so if that's also the case for POTC, I think $800-900 million is a reasonable projection, once you factor in franchise fatigue, Chinese growth and the exchange rates.

Perhaps I'm out of touch given the low predictions bit ill go with:
Dom: $206
WW: $938
A continued drop off domestically although not off a cliff like many feel as I find that this franchise has a following. I think a drop WW is inevitable given Depps falling star but the last one stunk and still made over a billion. I think it's one of those franchises that the oversees crowd just inexplicably loves (see Fast and Furious franchise as well as Tramsformers).

175M Dom
680 OS
=855M WW

OW: $90 million
DOM: $220 million
INTL: $780 million
WW: $1,000 billion

$150 domestic, $700 million overseas.

There have been surprises before, but I don't see how this outgrosses the previous film domestically.

$88 million OW
$250 million domestic
$950 million WW
TEAM CAP

To follow my answer to Trev - and to be Daily Mail-precise - the overrun 'was' $70 mil. over greenlighted budget of $250 mil. and with production far from over.
Personally I definitely can see this movie costing close to $300 mil. after rebates.
But to move towards or beyond $400 for the second time in a row - after hiring cheapest and experience-ed directors available (two for the price of half-Rob Marshall I bet and might add) and doing everything,including reserving 2 years for post, in their power to avoid overruns - would truly be something.
Should that be true - Nic Cage will never see another "National Treasure"-paycheck, that's for sure.

400 million, that would be 10 million cheaper than the last one, good job.

Well, the main source is Daily Mail.
So it can either be true or Daily Mail.

The problem is that there are (unconfirmed by respected sources) rumors that it went way over budget and might finish costing around the last one, i.e. ~$400 mil.
$800m seems about right, though the budget rumors surprise me. I was under the impression that the reason for the incredibly long post-production period (it shot back in Spring 2015, more than two years before the release date) was to avoid all the massive cost overruns on the last two films when they were rushing to meet the release date and pouring money into the effects to get them ready in time. Even with three weeks of reshoots in Spring, it doesn't seem like there was major surgery, though this has been one of those franchises that has a lot of built-in problems that drive budget overruns - not least filming at sea.
"Security - release the badgers."

$800 mil. WW seems like a safe bet.
The problem is that there are (unconfirmed by respected sources) rumors that it went way over budget and might finish costing around the last one, i.e. ~$400 mil.

It might make 900 million dollars worldwide.
Last Films seen:
Fantastic Four(2015)- 5/10
Sully(2016)- 8/10
Don't Breath(2016)- 9/10

Them only mentioning Jack Sparrow (and not seeing him) was a cool move, I thought. It gives the impression that they're whetting the appetite before his "return shot" in the main trailer.
Skipping page long posts for over a year now.

Trailer is out:
I just took a quick look, not sure they use any establish character in the trailer (no Sparrow at least), the guy look like he could be playing Orlando Bloom son.
It look like a giant event affair with the giant score and all, it is hard to imagine dropping that much from the 4.

Did we really need another one of these?
Anyway, I think it will do alright in the US and put up huge numbers overseas, but franchise fatigue could definitely be in full swing here.

I think we're going to see a lot of growth in some markets and a lot of dipping in others.
The last one despite being called every negative term in the book on IMDB made a billion despite the name calling. And the difference between this and Alice is the POTC formula. It hasn't been tried since The Lone Ranger so its something different for both Depp and Disney next summer. That won't however save this long awaited movie from doing bad bussiness in some countries.
My prediction:
180M Domestic
300M China
400M Other markets
880M WW

And it's worth noting that even as a flop, Alice 2 pulled in $299m despite the generally turgid reputation of the first film.
This, 300 million is an impressive amount for something that look like it flopped so much.
Could have made 340 million with a more standard exchange rate and not be perceived as a flop.
Lost at least 10.5 (euro) + 2.57 (pound) + 8.6 (rouble) + 5.15 (real) vs 2014 summer.

Actually Alice opened the same day the abuse allegations came out, so that perhaps had the worst timing and impact possible.
But as you can see, I'm not predicting big things for the film and think even an outright flop is possible.

The movie made almost 800 million overseas. Not sure what you mean by "the movie was disliked"

Was I speaking in a different language? Because I'm pretty sure I clearly said that neither Ice Age nor Terminator is as big as POTC 'domestically'. And in any case you are wrong because POTC has had 3 billion plus grossers. How many did Ice Age have?