My picks:

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Lyceus — 12 years ago(October 12, 2013 11:00 AM)

Scorpius (Farscape) is the first one that always comes to my mind when this question is asked.
And maybe some Doctor Who villains, like the Daleks and the Weeping Angels.

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VIsraWratS — 12 years ago(March 19, 2014 09:27 PM)

Yes, Scorpius is one of the best villains ever.

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beckyx1 — 12 years ago(November 19, 2013 05:52 PM)

Brendan Brady (Hollyoaks)

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QueenOfChaos — 12 years ago(April 08, 2014 05:27 AM)

Yes! Brendan was awesome.
More about me:
ej386.wordpress.com

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beckyx1 — 12 years ago(April 08, 2014 06:54 AM)

ikr!? Hollyoaks has gone so down hill without him!

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neo_noir777777 — 12 years ago(November 19, 2013 08:50 PM)

My picks:
Marlo Stanfield (The Wire)
Gus Fring (Breaking Bad)
Gyp Rosetti (Boardwalk Empire)
Ralph Cifero (The Sopranos)
Vern Schillinger (Oz)
T-Bag (Prison Break)
Great picks.
I'd like to add:
The Trinity Killer (Dexter)
Walter White (Breaking Bad - if you can consider him a villain by the show's end)
Jim Moriarty (Sherlock BBC)
The Ice Truck Killer (Dexter)

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veikkohoffman — 12 years ago(November 29, 2013 02:24 PM)

Gus Fring from Breaking Bad and T-Bag from Prison Break

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nightwatch4773 — 12 years ago(November 30, 2013 03:06 PM)

Trinity from Dexter by a landslide!!!!!!!!!!!!!

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cheepic — 12 years ago(December 02, 2013 12:11 PM)

• Yes

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crazyforblondes — 12 years ago(January 11, 2014 04:06 AM)

Gus Fring (Breaking Bad)
Ben Linus (Lost)
Trinity Killer (Dexter)
Sylar (Heroes)

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billh1948 — 12 years ago(January 12, 2014 05:21 AM)

The Trickster - Supernatural

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dharma-dave — 9 years ago(May 28, 2016 08:09 AM)

Ben Linus
Smoke Monster
White Walkers

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movieman82us — 9 years ago(August 06, 2016 02:21 AM)

Boyd Crowder
Arvin Sloane
Irina Derevko
Julian Sark
Charles Logan
Christopher Henderson
Nina Myers
Sherry Palmer
Ramon Salazar
Cheng Zhi
John Greer
Azazel (AKA Yellow Eyed Demon)
Lucifer
Slade Wilson
Shane Walsh
The Governor
Wilson Fisk
Victoria and Conrad Grayson
Joe Carroll
Note: I don't consider Benjamin Linus to be a villain. Sure, he was at first, but by the end of the series he was on the good side.
I also considered putting Tony Almeida on my list since he's a good character turned bad, but like Benjamin Linus, I'm not sure he really counts as a full on villain.